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Background:
Early onset colorectal cancer (EO CRC) is rising worldwide. Epidemiologic studies have shown that diets high in sugar and/or processed foods and limited exercise are associated with EO CRC when compared to healthy controls. However, risk factors associated with de novo metastatic disease are less well established. Identifying such risk factors may provide insight into modifiable lifestyle variables.
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¦µo©Ê¤j¸zª½¸zÀù (EO CRC) ¦b¥þ²y½d³ò¤º§e¤W¤ÉÁͶաC ¬y¦æ¯f¾Ç¬ã¨sªí©ú¡A»P°·±d¹ï·Ó²Õ¬Û¤ñ¡A°ª¿}¶¼¹©M/©Î¥[¤u¹«~¥H¤Î¯Ê¥F¹B°Ê»P EO CRC ¬ÛÃö¡CµM¦Ó¡A»P·s¥ÍÂಾ©Ê¯e¯f¬ÛÃöªº¦MÀI¦]¤l©|¤£©ú½T¡CÃѧO³o¨Ç·ÀI¦]¯À¥i¯à¦³§U©ó²`¤J¤F¸Ñ¥i§ïÅܪº¥Í¬¡¤è¦¡ÅܼơC
Conclusions:
In a single center study, in EO CRC patients, high sugar diets may be associated with de novometastatic disease. There were no significant genomic differences detected in patients with de novo metastatic vs. early stage disease.
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